From my experience, the migration to 4.3 wasn't smooth and this has been with every 4.X number release, since 4.1. If you don't have really a lot of members or it's a gaming board, then, I suppose, it's just fine (I don't remember if it was marked as a critical security update, though). Most of the themes and plugins work just fine, without the need of an upgrade (4.1 -> 4.2), what made the upgrade not so smooth were the customizations to the code I had made.
Long story short: it may have some bumps here and there but it generally should be fine. The custom code you may have added could be the only problem.
Edit: I forgot that the latest release is 4.4.3. As far as I remember, 4.2.2 dates back to the summer of 2017 and you may really want to go to the newest version. You've been at 4.2.2 for a while and there were several critical security updates since then, a few of them related to adminCP security.